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Waldenström macroglobulinemia in hepatitis C: case report and review of the current literature.
[waldenström macroglobulinemia]
Background
.
Recent
literature
has
associated
hepatitis
C
virus
with
the
development
of
non-
Hodgkin
lymphoma
.
Hepatitis
C
virus
infection
appears
to
promote
lymphoproliferation
,
providing
a
plausible
mechanism
for
a
causative
association
;
however
,
despite
prior
reports
of
patients
with
comorbid
hepatitis
C
infection
and
Waldenström
macroglobulinemia
,
the
literature
is
in
disagreement
regarding
whether
there
exists
an
association
between
these
two
conditions
.
Case
Presentation
.
This
case
report
describes
a
57
-
year
-old
African-
American
male
with
chronic
hepatitis
C
infection
and
cryoglobulinemia
who
presented
with
several
episodes
of
transient
confusion
and
paralysis
and
was
found
to
have
symptomatic
hyperviscosity
.
The
recognition
of
his
condition
was
facilitated
by
characteristic
findings
on
ophthalmologic
examination
.
He
was
subsequently
diagnosed
with
Waldenström
macroglobulinemia
on
bone
marrow
biopsy
.
Conclusions
.
An
up
to
date
,
comprehensive
review
of
the
literature
suggests
an
association
between
hepatitis
C
and
Waldenström
macroglobulinemia
.
Data
on
optimal
treatment
of
patients
with
comorbid
hepatitis
C
infection
and
Waldenström
macroglobulinemia
is
limited
.
We
have
provided
a
comprehensive
review
of
previously
explored
treatment
options
to
guide
management
of
other
similar
patients
.
Our
patient
has
since
been
treated
with
repeated
plasmapheresis
with
a
plan
to
pursue
antiviral
therapy
.
