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A paroxysmal nocturnal haemoglobinuria progress with waldenström macroglobulinemia along with T cell monoclonal expansion.
[waldenström macroglobulinemia]
Paroxysmal
nocturnal
hemoglobinuria
(
PNH
)
is
an
acquired
hematopoietic
stem
cell
clinical
disease
,
which
has
been
reported
associated
with
T
cell
monoclonal
expansion
and
plasma
cell
dyscrasias
.
There
we
reported
a
case
with
a
20
-
year
clinical
history
of
PNH
.
Lately
diagnosis
of
Waldenström
macroglobulinemia
with
the
offered
evidences
of
bone
marrow
examination
,
flow
cytometry
and
immunofixation
electrophoresis
.
T
cell
monoclonal
expansion
was
established
by
polymerase
chain
reaction
.
Meanwhile
the
decreased
expression
of
CD
55
and
CD
59
on
neutrophils
and
erythrocyte
were
obvious
observed
.
Here
we
describe
the
diagnostic
evaluation
of
this
patient
and
provide
a
brief
review
of
such
clonal
disorder
.
