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17β-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice.
[aromatase deficiency]
Aromatase-
deficient
(
ArKO
)
mice
are
totally
anovulatory
due
to
insufficient
estrogen
production
.
However
,
sequential
administrations
of
high
doses
of
17
β-estradiol
(
E
2
)
and
gonadotropins
were
found
to
induce
ovulation
in
these
mice
.
Here
,
we
examined
how
the
ovulatory
stimulation
for
ArKO
mice
alters
the
expressions
of
genes
related
to
prostaglandin
(
PG
)
E
(
2
)
metabolism
and
ovarian
contents
of
PGE
(
2
)
,
as
PGE
(
2
)
is
one
of
the
critical
mediators
of
ovulatory
induction
.
The
ovulatory
stimulation
significantly
increased
mRNA
expressions
of
prostaglandin-endoperoxide
synthase
2
,
PGE
(
2
)
receptor
type
4
and
sulfotransferase
family
1
E
,
member
1
,
in
preovulatory
ArKO
ovaries
.
In
contrast
,
it
suppressed
the
mRNA
expression
of
15
-
hydroxyprostaglandin
dehydrogenase
.
Furthermore
,
significant
elevation
in
the
PGE
(
2
)
contents
was
detected
in
the
preovulatory
ovaries
of
ArKO
mice
after
stimulation
with
E
2
plus
ovulatory
doses
of
gonadotropins
.
Thus
,
these
analyses
demonstrate
a
requirement
of
E
2
for
the
preovulatory
enhancement
of
PGE
(
2
)
synthesis
,
leading
to
future
success
in
ovulation
.
Diseases
Validation
Diseases presenting
"high doses"
symptom
allergic bronchopulmonary aspergillosis
aromatase deficiency
classical phenylketonuria
cushing syndrome
erdheim-chester disease
homocystinuria without methylmalonic aciduria
severe combined immunodeficiency
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