Rare Diseases Symptoms Automatic Extraction

Sunitinib treatment for metastatic renal cell carcinoma in patients with von hippel-lindau disease.

[von hippel-lindau disease]

Von Hippel-Lindau (VHL) disease is an autosomal dominant disease that produces a variety of tumors and cysts in the central nervous system and visceral organs, including renal cell carcinoma (RCC). RCC in patients with VHL disease does not frequently metastasize, therefore, the response to treatment and prognosis of metastatic RCC developed in patients with VHL disease has not been reported. Sunitinib is an oral, multitargeted receptor tyrosine kinase inhibitor with antiangiogenic and antitumor activity. Here, we report on four patients with metastatic RCC in VHL disease who received sunitinib and achieved partial responses that have lasted for a prolonged period of time.

Diseases presenting "renal cell carcinoma" symptom

  • cowden syndrome
  • dedifferentiated liposarcoma
  • esophageal adenocarcinoma
  • esophageal squamous cell carcinoma
  • liposarcoma
  • pleomorphic liposarcoma
  • severe combined immunodeficiency
  • systemic capillary leak syndrome
  • von hippel-lindau disease

This symptom has already been validated