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The clinical outcome of intracranial hemangioblastomas treated with linac-based stereotactic radiosurgery and radiotherapy.
[von hippel-lindau disease]
Recent
publications
have
reported
stereotactic
radiosurgery
as
an
effective
and
safe
treatment
for
intracranial
hemangioblastomas
.
However
,
because
of
the
low
incidence
of
these
particular
tumors
,
reports
on
large
patient
number
studies
have
not
yet
been
available
.
The
objective
of
this
study
was
to
analyze
the
clinical
results
of
14
patients
with
56
intracranial
hemangioblastomas
treated
with
linear
accelerator
(
linac
)
-
based
stereotactic
radiosurgery
(
SRS
)
and
radiotherapy
(
SRT
)
in
the
same
institute
.
The
median
age
of
patients
was
41
years
(
range
,
28
-
73
years
)
.
Nine
of
the
patients
(
64
%
)
had
von
Hippel-
Lindau
disease
.
A
total
of
39
lesions
(
70
%
)
were
treated
with
CyberKnife
(
CK
)
,
and
17
lesions
(
30
%
)
were
treated
with
X-Knife
.
The
median
pretreatment
volume
was
0
.
26
cm
(
3
)
(
range
,
0
.
026
-
20
.
4
cm
(
3
)
)
.
The
median
marginal
dose
was
20
Gy
(
range
,
10
-
32
Gy
)
in
1
fraction
(
range
,
1
-
10
fractions
)
.
The
median
follow-up
time
was
24
months
(
range
,
11
-
89
months
)
.
At
the
last
follow-up
,
47
tumors
(
84
%
)
were
stable
,
7
(
13
%
)
decreased
and
2
(
4
%
)
increased
.
The
1
-
,
2
-
and
6
-
year
local
control
rates
were
98
%
,
88
%
and
73
%
,
respectively
.
No
radiation
complications
were
observed
in
this
study
.
There
was
a
trend
toward
local
failure
only
in
cystic
tumors
,
but
this
trend
was
not
found
to
be
statistically
significant
.
SRS
/
SRT
achieved
a
high
local
control
rate
in
intracranial
hemangioblastomas
without
radiation-induced
complications
.
Diseases
Validation
Diseases presenting
"intracranial hemangioblastomas"
symptom
von hippel-lindau disease
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