Surgical management of pancreatic neuroendocrine neoplasms.

[von hippel-lindau disease]

Pancreatic neuroendocrine neoplasms are relatively rare entities , representing approximately 1 % to 2 % of all pancreatic tumors . Owing to their rarity as well as their relatively indolent natural history , treatment approaches are not yet standardized . A formal pancreatic resection is usually mandatory for large and localized sporadic pancreatic tumors or in the presence of symptoms . However , in small and asymptomatic lesions , a conservative approach consisting in a careful wait-and-see policy is going to appear as more appropriate , particularly when , to remove the lesion , an aggressive surgical procedure is required , such as pancreaticoduodenectomy or distal splenopancreatectomy , depending on the localization of the tumor . Surgery has also a significant role in locally advanced and metastatic forms . In the setting of MEN 1 syndrome or Von -Hippel Lindau disease , the tumor size and the possible symptoms should be considered in the evaluation of a proper treatment .

Diseases
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Diseases presenting "depending on the localization of the tumor" symptom

von hippel-lindau disease

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