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Sex steroids and bone health status in men.
[aromatase deficiency]
Male
osteoporosis
is
a
health
problem
which
deserves
more
attention
as
nearly
30
%
of
osteoporotic
fractures
happen
in
men
aged
50
years
and
above
.
Although
men
do
not
experience
an
accelerated
bone
loss
phase
and
testosterone
deficiency
is
not
a
universal
characteristic
for
aged
men
,
osteoporosis
due
to
age-related
testosterone
deficiency
does
have
a
negative
impact
on
bone
health
status
of
men
.
Observations
from
epidemiological
studies
indicate
that
elderly
men
with
higher
testosterone
can
preserve
their
BMD
better
and
thus
are
less
prone
to
fracture
.
Observations
on
men
with
estrogen
resistance
or
aromatase
deficiency
indicate
that
estrogen
is
equally
important
in
the
maintenance
of
bone
health
status
.
This
had
been
validated
in
several
epidemiological
studies
which
found
that
the
relationships
between
estrogen
and
bone
health
indices
are
significant
and
sometimes
stronger
than
testosterone
.
Studies
on
the
relationship
between
quantitative
ultrasound
and
bone
remodeling
markers
suggest
that
testosterone
and
estrogen
may
have
differential
effects
on
bone
,
but
further
evidence
was
needed
.
In
conclusion
,
both
testosterone
and
estrogen
are
important
in
the
maintenance
of
bone
health
in
men
.
