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Vaccine-induced inflammation attenuates the vascular responses to mental stress.
[typhoid]
Inflammation
is
associated
with
poorer
vascular
function
,
with
evidence
to
suggest
that
inflammation
can
also
impair
the
vascular
responses
to
mental
stress
.
This
study
examined
the
effects
of
vaccine-induced
inflammation
on
vascular
responses
to
mental
stress
in
healthy
participants
.
Eighteen
male
participants
completed
two
stress
sessions
:
an
inflammation
condition
having
received
a
typhoid
vaccination
and
a
control
(
non-inflamed
)
condition
.
Tumor
necrosis
factor
-alpha
and
interleukin-
6
(
p
's
<
.
001
)
increased
following
vaccination
,
confirming
modest
increases
in
inflammation
.
Mental
stress
increased
blood
flow
,
blood
pressure
,
heart
rate
,
and
cardiac
output
in
both
conditions
(
all
p
's
<
.
001
)
,
but
the
blood
flow
response
to
stress
was
attenuated
having
received
the
vaccination
compared
to
the
control
condition
(
p
's
<
.
05
)
.
These
results
further
implicate
the
interaction
between
inflammation
and
the
vasculature
as
a
mechanism
through
which
stress
may
trigger
myocardial
infarction
.