False positive malaria rapid diagnostic test in returning traveler with typhoid fever.

[typhoid]

Rapid diagnostic tests play a pivotal role in the early diagnosis of malaria where microscopy or polymerase chain reaction are not immediately available .We report the case of a 39 year old traveler to Canada who presented with fever , headache , and abdominal pain after visiting friends and relatives in India . While in India , the individual was not ill and had no signs or symptoms of malaria . Laboratory testing upon his return to Canada identified a false positive malaria rapid diagnostic (BinaxNOW ® malaria ) result for P . falciparum with coincident Salmonella Typhi bacteraemia without rheumatoid or autoimmune factors . Rapid diagnostic test false positivity for malaria coincided with the presence or absence of Salmonella Typhi in the blood .Clinicians should be aware that Salmonella Typhi infection may result in a false positive malaria rapid diagnostic test . The mechanism of this cross-reactivity is not clear .

Diseases
Validation

Diseases presenting "fever" symptom

22q11.2 deletion syndrome

acute rheumatic fever

alexander disease

allergic bronchopulmonary aspergillosis

canavan disease

carcinoma of the gallbladder

child syndrome

congenital toxoplasmosis

cushing syndrome

cystinuria

dracunculiasis

erdheim-chester disease

esophageal adenocarcinoma

esophageal carcinoma

familial mediterranean fever

focal myositis

hodgkin lymphoma, classical

lamellar ichthyosis

legionellosis

locked-in syndrome

malignant atrophic papulosis

neonatal adrenoleukodystrophy

neuralgic amyotrophy

oculocutaneous albinism

papillon-lefèvre syndrome

pyomyositis

pyruvate dehydrogenase deficiency

scrub typhus

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

typhoid

waldenström macroglobulinemia

wolf-hirschhorn syndrome

This symptom has already been validated