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Review on prescription compatibility of shaoyao gancao decoction and reflection on pharmacokinetic compatibility mechanism of traditional chinese medicine prescription based on in vivo drug interaction of main efficacious components.
[typhoid]
Shaoyao
Gancao
Decoction
(
SGD
)
derived
from
Zhang
Zhongjing
's
"
Typhoid
Theory
"
is
composed
of
peony
and
licorice
,
having
the
efficacy
of
nourishing
liver
,
relaxing
spasm
,
and
relieving
pain
.
Modern
compatibility
studies
of
SGD
on
chemistry
,
pharmacology
,
and
pharmacokinetics
all
demonstrate
the
reasonable
compatibility
of
peony
and
licorice
.
However
,
the
present
research
on
pharmacokinetics
is
only
descriptive
and
limited
to
the
influence
on
in
vivo
dynamic
process
of
certain
ingredients
;
correspondingly
,
there
is
lack
of
studies
on
the
essence
of
these
efficacious
substances
'
in
vivo
changes
;
that
is
,
whether
it
is
because
there
exists
in
vivo
drug
interaction
in
absorption
,
distribution
,
metabolism
,
and
excretion
(
ADME
)
of
active
ingredients
that
leads
to
the
improvement
of
bioavailability
.
We
herein
take
SGD
as
an
example
and
suggest
that
it
is
necessary
to
study
in
vivo
drug
interaction
of
main
efficacious
components
mediated
by
metabolic
enzymes
,
transport
proteins
,
or
plasma
protein
binding
in
the
course
of
ADME
,
which
is
helpful
to
illustrate
the
principle
of
pharmacokinetic
compatibility
from
the
essence
leading
to
the
changes
of
effective
substances
in
vivo
.
Diseases
Validation
Diseases presenting
"main efficacious components"
symptom
typhoid
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