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Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever.
[typhoid]
Salmonella
enterica
serovar
Typhi
,
the
cause
of
typhoid
,
is
host
restricted
to
humans
.
S
.
Typhi
has
a
monophyletic
population
structure
,
indicating
that
typhoid
in
humans
is
a
relatively
new
disease
.
Antimicrobial
usage
is
reshaping
the
current
S
.
Typhi
global
population
and
may
be
driving
the
emergence
of
a
specific
haplotype
,
H
58
,
that
is
well
adapted
to
transmission
in
modern
settings
and
is
able
to
resist
antimicrobial
killing
more
efficiently
than
other
S
.
Typhi
.
Evidence
gathered
through
genomics
and
functional
studies
using
the
mouse
and
in
vitro
cell
systems
,
together
with
clinical
investigations
,
has
provided
insight
into
the
mechanisms
that
underpin
the
pathogenesis
of
human
typhoid
and
host
restriction
.
Here
we
review
the
latest
scientific
advances
in
typhoid
research
and
discuss
how
these
novel
approaches
are
changing
our
understanding
of
the
disease
.
Diseases
Validation
Diseases presenting
"provided insight into the mechanisms"
symptom
typhoid
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