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Comparative evaluation of safety and efficacy of a live Salmonella gallinarum vaccine candidate secreting an adjuvant protein with SG9R in chickens.
[typhoid]
We
previously
reported
JOL
916
,
a
live
attenuated
Salmonella
gallinarum
(
SG
)
,
as
a
vaccine
candidate
for
protection
from
fowl
typhoid
(
FT
)
.
In
the
present
study
,
we
evaluated
JOL
1355
,
an
SG
that
secretes
heat-labile
enterotoxin
B
subunit
protein
,
for
safety
,
immunogenicity
,
and
protective
efficacy
against
FT
.
In
a
single
intramuscular
inoculation
,
live
attenuated
SG
(
JOL
916
)
and
commercial
live
attenuated
SG
9
R
immunized
groups
showed
gross
lesions
and
bacterial
persistence
up
to
21
days
post-immunization
.
However
,
the
JOL
1355
immunized
group
showed
gross
lesions
and
bacterial
persistence
up
to
only
3
and
7
days
post-immunization
,
respectively
.
In
addition
,
several
birds
in
the
JOL
916
and
SG
9
R
immunized
group
shown
clinical
signs
after
immunization
,
while
JOL
1355
immunized
birds
did
not
show
any
adverse
effects
.
In
a
subsequent
study
,
birds
were
primed
and
boosted
at
4
and
8
weeks
of
age
,
respectively
,
and
compared
with
control
birds
inoculated
with
sterile
phosphate-buffered
saline
.
The
immunized
groups
B
(
JOL
916
)
,
C
(
SG
9
R
)
,
and
D
(
JOL
1355
)
exhibited
significantly
higher
humoral
and
cellular
immune
responses
compared
to
those
in
the
unimmunized
control
group
A
.
In
addition
,
the
birds
of
each
group
were
challenged
with
virulent
SG
at
11
weeks
of
age
,
and
significantly
increased
survival
rates
were
observed
in
all
immunized
groups
compared
with
the
control
group
.
These
results
indicated
that
JOL
1355
was
able
to
efficiently
induce
an
acquired
immune
response
to
protect
birds
after
challenge
,
and
may
be
safer
than
JOL
916
and
the
commercial
vaccine
SG
9
R
in
chickens
.
Diseases
Validation
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"increased survival rates"
symptom
typhoid
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