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Antityphoid and radical scavenging properties of the methanol extracts and compounds from the aerial part of Paullinia pinnata.
[typhoid]
Paullinia
pinnata
Linn
(
Sapindaceae
)
is
a
medicinal
plant
,
locally
used
in
the
West
Region
of
Cameroon
for
the
treatment
of
typhoid
fever
.
This
work
was
designed
to
evaluate
the
antityphoid
and
antioxidant
activities
of
the
extracts
and
compounds
of
P
.
pinnata
.
The
methanol
extracts
of
the
leaves
and
stems
were
tested
for
antityphoid
and
antioxidant
activities
.
Compounds
were
isolated
,
and
their
structures
elucidated
by
analysis
of
spectroscopic
data
in
conjuction
with
literature
data
and
tested
for
the
same
activities
.
The
leaf
extract
was
also
tested
in
vivo
for
its
antityphoid
potential
in
a
Salmonella
typhimurium-induced
typhoid
fever
model
in
Wistar
rats
.
Seven
known
compounds
:
methylinositol
(
1
)
,
β-sitosterol
(
2
)
,
friedelin
(
3
)
,
3
β-
(
β-
D-Glucopyranosyloxy
)
stigmast-
5
-
ene
(
4
)
,
(
3
β
)
-
3
-
O-
(
2
'
-
Acetamido-
2
'
-
deoxy-β-
D-
glucopyranosyl
)
oleanolic
acid
(
5
)
,
(
3
β
,
16
α-hydroxy
)
-
3
-
O-
(
2
'
-
Acetamido-
2
'
-
deoxy-β-
D-
glucopyranosyl
)
echinocystic
acid
(
6
)
and
(
3
β
,
)
-
3
-
O-
[
β-
D-
glucopyranosyl-
(
1
″
-
3
'
)
-
2
'
-
acetamido-
2
'
-
deoxy-β-
D-
galactopyranosyl
]
oleanolic
acid
(
7
)
were
isolated
.
Compounds
5
and
1
showed
the
highest
antibacterial
(
MIC
=
0
.
781
-
1
.
562
μg
/
ml
)
and
DPPH
radical
scavenging
(
RSa
50
=
19
.
27
±
4
.
43
μg
/
ml
)
activities
respectively
.
The
maximum
extract
dose
(
446
.
00
mg
/
kg
bw
)
had
comparable
activity
with
ciprofloxacin
(
7
.
14
mg
/
kg
bw
)
and
oxytetracycline
(
5
mg
/
kg
bw
)
.
The
extract
induced
significant
dose-dependent
increase
of
WBCs
and
lymphocytes
.
These
results
support
the
ethnomedicinal
use
of
P
.
pinnata
and
its
isolated
Compounds
could
be
useful
in
the
standardization
of
antityphoid
phytomedicine
from
it
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated
