Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy.
[typhoid]
to
describe
non-spesific
and
specific
immune
response
profile
in
Indonesian
thalassemia
major
with
and
without
splenectomy
.
this
study
was
held
at
Thalassaemia
Centre
,
Cipto
Mangunkusumo
Hospital
Jakarta
on
September
2013
-
February
2014
.
A
comparative
cross
sectional
study
was
conducted
in
healthy
,
thalassemia
major
aged
more
than
12
year
and
seronegative
HIV
.
They
were
matched
in
age
and
sex
for
splenectomised
and
non-splenectomised
groups
,
analysing
the
non-spesific
immune
response
(
neutrophil
count
and
phagocytosis
)
and
specific
immune
response
(
count
and
function
of
cellular
immunity
)
.
Infection
episodes
were
also
analized
as
immune
response
in
vivo
parameter
.
splenectomised
thalassemia
major
showed
increased
neutrophil
count
but
significantly
decreased
non-spesific
immune
response
(
neutrophil
phagocytosis
)
.
Spesific
immune
response
of
splenectomised
group
presented
significantly
higher
absolute
lymphocyte
,
lymphocyte
T
,
CD
4
+
and
CD
8
+
counts
compared
to
non-splenectomised
thalassemia
major
(
p
<
0
.
05
)
.
Ratio
CD
4
+
/
CD
8
+
were
similar
in
these
groups
.
Serum
marker
of
activated
cellular
imunity
function
(
IL
-
2
and
TNF
-
)
were
similar
among
two
groups
.
Mild
infection
episodes
on
splenectomised
and
non-splenectomised
group
were
2
.
02
(
ranged
0
to
12
)
times
and
0
.
81
(
ranged
0
to
8
)
times
(
p
=
0
.
004
)
,
respectively
.
Severe
infection
on
splenectomised
group
were
sepsis
for
2
weeks
and
diarrhea
for
1
week
,
whereas
on
non-splenectomised
group
was
typhoid
fever
for
4
days
.
there
were
significant
differences
on
immune
response
among
thalassemia
major
patients
.
Splenectomised
thalassemia
major
showed
a
greater
degree
of
susceptibility
to
infections
than
non-splenectomised
thalassemia
major
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated