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Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy.
[typhoid]
to
describe
non-spesific
and
specific
immune
response
profile
in
Indonesian
thalassemia
major
with
and
without
splenectomy
.
this
study
was
held
at
Thalassaemia
Centre
,
Cipto
Mangunkusumo
Hospital
Jakarta
on
September
2013
-
February
2014
.
A
comparative
cross
sectional
study
was
conducted
in
healthy
,
thalassemia
major
aged
more
than
12
year
and
seronegative
HIV
.
They
were
matched
in
age
and
sex
for
splenectomised
and
non-splenectomised
groups
,
analysing
the
non-spesific
immune
response
(
neutrophil
count
and
phagocytosis
)
and
specific
immune
response
(
count
and
function
of
cellular
immunity
)
.
Infection
episodes
were
also
analized
as
immune
response
in
vivo
parameter
.
splenectomised
thalassemia
major
showed
increased
neutrophil
count
but
significantly
decreased
non-spesific
immune
response
(
neutrophil
phagocytosis
)
.
Spesific
immune
response
of
splenectomised
group
presented
significantly
higher
absolute
lymphocyte
,
lymphocyte
T
,
CD
4
+
and
CD
8
+
counts
compared
to
non-splenectomised
thalassemia
major
(
p
<
0
.
05
)
.
Ratio
CD
4
+
/
CD
8
+
were
similar
in
these
groups
.
Serum
marker
of
activated
cellular
imunity
function
(
IL
-
2
and
TNF
-
)
were
similar
among
two
groups
.
Mild
infection
episodes
on
splenectomised
and
non-splenectomised
group
were
2
.
02
(
ranged
0
to
12
)
times
and
0
.
81
(
ranged
0
to
8
)
times
(
p
=
0
.
004
)
,
respectively
.
Severe
infection
on
splenectomised
group
were
sepsis
for
2
weeks
and
diarrhea
for
1
week
,
whereas
on
non-splenectomised
group
was
typhoid
fever
for
4
days
.
there
were
significant
differences
on
immune
response
among
thalassemia
major
patients
.
Splenectomised
thalassemia
major
showed
a
greater
degree
of
susceptibility
to
infections
than
non-splenectomised
thalassemia
major
.
Diseases
Validation
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"specific immune response profile in indonesian thalassemia"
symptom
typhoid
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