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Suppression of dendritic cell and T-cell activation by the pRST98 Salmonella plasmid.
[typhoid]
Salmonella
evades
host
immune
response
via
the
expression
of
a
variety
of
pathogenic
factors
.
The
'
pRST
98
'
plasmid
of
Salmonella
enterica
serotype
Â
Typhi
(
S
.
Â
Typhi
)
is
involved
in
conferring
the
multidrug‑resistance
and
virulence
of
S
.
Â
typhi
.
However
,
its
specific
effect
on
host‑cell
function
has
remained
elusive
.
Dendritic
cells
(
DCs
)
are
key
regulators
of
immune
responses
.
The
present
study
therefore
aimed
to
investigate
whether
pRST
98
may
target
DCs
involved
in
mediating
the
adaptive
immune
response
.
In
Â
vivo
experiments
with
Salmonella
Â
enterica
serotype
Typhimurium
χ
3337
and
χ
3337
/
pRST
98
revealed
that
pRST
98
may
influence
multiple
important
functions
of
murine
DCs
,
including
maturation
,
survival
and
cytokine
production
.
In
addition
,
pRST
98
markedly
contributed
to
decreasing
T
‑
cell
activation
.
These
data
suggested
that
by
targeting
the
aforementioned
functions
of
DCs
,
pRST
98
may
partially
overturn
the
adaptive
immune
defense
mechanisms
of
the
host
,
which
are
required
for
elimination
of
this
pathogen
from
infected
tissues
.
This
may
contribute
to
the
evasion
of
host
adaptive
immune
responses
by
S
.
Â
Typhi
and
therefore
provide
a
target
for
the
prevention
and
treatment
of
typhoid
fever
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated