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Risk factors and the evolution of psychosis in 22q11.2 deletion syndrome: a longitudinal 2-site study.
[22q11.2 deletion syndrome]
22
q
11
.
2
Deletion
syndrome
(
22
q
11
.
2
DS
)
is
associated
with
high
rates
of
schizophrenia
,
other
neuropsychiatric
disorders
,
and
cognitive
deficits
.
The
objectives
of
this
2
-
center
study
were
to
longitudinally
assess
the
trajectories
of
psychiatric
disorders
in
22
q
11
.
2
DS
from
childhood
to
adulthood
,
and
to
identify
risk
factors
for
their
emergence
.
A
total
of
125
children
and
adults
with
22
q
11
.
2
DS
were
evaluated
at
2
time
points
,
baseline
and
follow-up
(
4
years
apart
)
,
using
standardized
psychiatric
and
cognitive
measures
.
The
rate
of
mood
disorders
tended
to
decrease
during
childhood
and
increase
during
late
adolescence
.
Statistically
significant
predictors
for
the
presence
of
a
psychotic
disorder
as
well
as
the
severity
of
positive
symptoms
at
follow-up
were
identical
,
and
consisted
of
an
anxiety
disorder
at
baseline
,
lower
baseline
Full
Scale
IQ
,
and
a
greater
decrease
in
verbal
IQ
scores
between
time
points
.
Nine
of
10
individuals
with
an
emerging
psychotic
disorder
had
an
anxiety
disorder
at
baseline
.
The
age
of
onset
for
a
psychotic
disorder
was
between
14
and
22
years
in
82
.
6
%
of
cases
.
It
is
important
to
evaluate
the
presence
of
anxiety
disorders
in
children
and
adolescents
with
22
q
11
.
2
DS
,
as
they
are
major
risk
factors
for
the
emergence
of
psychotic
disorders
,
which
usually
occur
during
late
adolescence
in
this
at
-risk
population
.
Diseases
Validation
Diseases presenting
"cognitive deficits"
symptom
22q11.2 deletion syndrome
alexander disease
classical phenylketonuria
cowden syndrome
cushing syndrome
hereditary cerebral hemorrhage with amyloidosis
krabbe disease
phenylketonuria
sneddon syndrome
triple a syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
This symptom has already been validated
