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Risk factors and the evolution of psychosis in 22q11.2 deletion syndrome: a longitudinal 2-site study.
[22q11.2 deletion syndrome]
22
q
11
.
2
Deletion
syndrome
(
22
q
11
.
2
DS
)
is
associated
with
high
rates
of
schizophrenia
,
other
neuropsychiatric
disorders
,
and
cognitive
deficits
.
The
objectives
of
this
2
-
center
study
were
to
longitudinally
assess
the
trajectories
of
psychiatric
disorders
in
22
q
11
.
2
DS
from
childhood
to
adulthood
,
and
to
identify
risk
factors
for
their
emergence
.
A
total
of
125
children
and
adults
with
22
q
11
.
2
DS
were
evaluated
at
2
time
points
,
baseline
and
follow-up
(
4
years
apart
)
,
using
standardized
psychiatric
and
cognitive
measures
.
The
rate
of
mood
disorders
tended
to
decrease
during
childhood
and
increase
during
late
adolescence
.
Statistically
significant
predictors
for
the
presence
of
a
psychotic
disorder
as
well
as
the
severity
of
positive
symptoms
at
follow-up
were
identical
,
and
consisted
of
an
anxiety
disorder
at
baseline
,
lower
baseline
Full
Scale
IQ
,
and
a
greater
decrease
in
verbal
IQ
scores
between
time
points
.
Nine
of
10
individuals
with
an
emerging
psychotic
disorder
had
an
anxiety
disorder
at
baseline
.
The
age
of
onset
for
a
psychotic
disorder
was
between
14
and
22
years
in
82
.
6
%
of
cases
.
It
is
important
to
evaluate
the
presence
of
anxiety
disorders
in
children
and
adolescents
with
22
q
11
.
2
DS
,
as
they
are
major
risk
factors
for
the
emergence
of
psychotic
disorders
,
which
usually
occur
during
late
adolescence
in
this
at
-risk
population
.
Diseases
Validation
Diseases presenting
"anxiety"
symptom
22q11.2 deletion syndrome
achondroplasia
adrenal incidentaloma
adrenomyeloneuropathy
cadasil
child syndrome
classical phenylketonuria
cohen syndrome
congenital adrenal hyperplasia
congenital toxoplasmosis
cutaneous mastocytosis
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
junctional epidermolysis bullosa
locked-in syndrome
monosomy 21
oligodontia
oral submucous fibrosis
phenylketonuria
von hippel-lindau disease
x-linked adrenoleukodystrophy
This symptom has already been validated
