Rare Diseases Symptoms Automatic Extraction

Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation.

[systemic capillary leak syndrome]

The pathophysiological mechanisms involved in the development of a spontaneous systemic capillary leak syndrome (CLS) are unknown. In contrast, CLS is a well-known side effect of high-dose interleukin-2 (IL-2) therapy in solid tumors. We report on a patient who developed CLS with high serum levels of endogenous IL-2 under immunosuppressive therapy for chronic graft-versus-host disease (GvHD) after allogeneic bone marrow transplantation (BMT). Generalized edema persisted for 10 weeks. The condition resolved after antibiotic therapy of a septic shock with beta hemolyzing streptococci group A. Thus, a latent infection may alter cytokine homeostasis and may cause CLS in BMT patients.

Diseases presenting "bone marrow transplantation" symptom

  • adrenomyeloneuropathy
  • cutaneous mastocytosis
  • erdheim-chester disease
  • erythropoietic protoporphyria
  • gm1 gangliosidosis
  • krabbe disease
  • oculocutaneous albinism
  • omenn syndrome
  • severe combined immunodeficiency
  • systemic capillary leak syndrome
  • wiskott-aldrich syndrome

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