Rare Diseases Symptoms Automatic Extraction
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Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation.
[systemic capillary leak syndrome]
The
pathophysiological
mechanisms
involved
in
the
development
of
a
spontaneous
systemic
capillary
leak
syndrome
(
CLS
)
are
unknown
.
In
contrast
,
CLS
is
a
well-known
side
effect
of
high
-dose
interleukin-
2
(
IL
-
2
)
therapy
in
solid
tumors
.
We
report
on
a
patient
who
developed
CLS
with
high
serum
levels
of
endogenous
IL
-
2
under
immunosuppressive
therapy
for
chronic
graft-versus-host
disease
(
GvHD
)
after
allogeneic
bone
marrow
transplantation
(
BMT
)
.
Generalized
edema
persisted
for
10
weeks
.
The
condition
resolved
after
antibiotic
therapy
of
a
septic
shock
with
beta
hemolyzing
streptococci
group
A
.
Thus
,
a
latent
infection
may
alter
cytokine
homeostasis
and
may
cause
CLS
in
BMT
patients
.
