Systemic capillary leak syndrome associated with multiple myeloma of IgG kappa type.

[systemic capillary leak syndrome]

A case of systemic capillary leak syndrome in a 67 -year -old woman is reported . The patient suddenly presented with severe edema and hypotension associated with an increased hematocrit and a decreased level of serum albumin , suggesting capillary hyperpermeability . The patient had IgG kappa monoclonal gammopathy in association with not only a slight increase in plasma cells in the bone marrow but also several punched out lesions in the skull , indicating multiple myeloma . Although most of the cases of systemic capillary leak syndrome reported previously were accompanied by monoclonal gammopathy , this appears to be the first case in which capillary leak syndrome developed in a patient with multiple myeloma .