[Periodically leaking capillaries].

[systemic capillary leak syndrome]

The systemic capillary leak syndrome (Clarkson 's syndrome ) is a rare idiopathic disorder , characterized by recurrent episodes of hypovolaemic shock , haemoconcentration and hypoalbuminaemia due to a sudden shift of fluid and macromolecules from the intravascular to the interstitial space . A young man is presented in whom recurrent attacks of hypotension and diffuse swelling were initially attributed to staphylococcal toxic shock syndrome . With the additional finding of a monoclonal gammopathy , the diagnosis of systemic capillary leak syndrome was made . Recognition of this syndrome is important , as prophylactic treatment with terbutaline and theophylline may be beneficial in this life threatening syndrome .