Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Gemcitabine-induced systemic capillary leak syndrome.
[systemic capillary leak syndrome]
Systemic
capillary
leak
syndrome
(
SCLS
)
is
a
rare
disorder
with
a
high
mortality
rate
,
characterized
by
rapidly
developing
edema
,
weight
gain
and
hypotension
,
hemoconcentration
and
hypoproteinemia
.
This
syndrome
is
caused
by
sudden
,
reversible
capillary
hyperpermeability
with
a
rapid
extravasation
of
plasma
from
the
intravascular
to
the
interstitial
space
.
Even
though
SCLS
has
been
suggested
to
be
the
pathogenic
mechanism
for
the
pulmonary
toxicity
of
gemcitabine
(
GCB
)
,
a
new
deoxycytidine
analogue
with
structural
similarities
to
cytosine
arabinoside
,
a
direct
correlation
between
GCB
and
SCLS
has
never
been
reported
.
We
describe
a
case
of
repeated
SCLS
after
GCB
administration
in
a
51
-
year
-old
male
with
locally-
advanced
non-
small
-cell
lung
cancer
treated
with
a
combination
of
cisplatin
and
GCB
.
The
detection
of
GCB-induced
SCLS
supports
the
hypothesis
that
SCLS
could
be
the
pathogenic
way
of
GCB
pulmonary
toxicity
.
This
finding
can
help
to
better
understand
and
treat
the
potentially
deadly
GCB-related
acute
respiratory
distress
syndrome
that
is
being
recognized
.
Diseases
Validation
Diseases presenting
"acute respiratory distress syndrome"
symptom
heparin-induced thrombocytopenia
legionellosis
scrub typhus
systemic capillary leak syndrome
typhoid
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom