Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Lethal systemic capillary leak syndrome associated with severe ventilator-induced lung injury: an experimental study.
[systemic capillary leak syndrome]
We
report
the
evolution
of
severe
ventilator-induced
lung
injury
associated
with
lethal
systemic
capillary
leak
syndrome
,
when
sheep
were
ventilated
at
a
peak
inspiratory
pressure
of
50
cm
H
2
O
,
at
a
respiratory
rate
of
8
breaths
.
min
,
with
an
inspiratory
time
of
2
.
5
secs
.
A
prospective
laboratory
animal
study
.
Experimental
animal
research
laboratory
.
Mixed
breed
sheep
.
Sheep
were
anesthetized
,
paralyzed
,
and
mechanically
ventilated
.
This
sheep
model
was
characterized
by
a
rapidly
evolving
massive
anasarca
,
hemoconcentration
,
cardiac
dysfunction
,
multiple
system
organ
failure
,
and
severe
ventilator-induced
lung
injury
.
Cardiovascular
changes
and
profound
hemoconcentration
developed
within
6
hrs
from
the
start
of
mechanical
ventilation
,
along
with
a
major
decline
in
pulmonary
compliance
and
deterioration
in
arterial
blood
gases
.
When
total
static
lung
compliance
decreased
to
0
.
15
mL
(
cm
H
2
O
)
(
-
1
)
x
kg
(
-
1
)
(
7
-
30
hrs
)
,
the
sheep
were
randomized
to
two
groups
.
Group
I
received
high
(
recruitive
)
positive
end-expiratory
pressure
(
9
-
20
cm
H
2
O
)
,
adjusted
as
needed
;
group
II
received
low
(
supportive
)
positive
end-expiratory
pressure
(
2
-
6
cm
H
2
O
)
.
Sheep
in
both
groups
progressively
deteriorated
and
died
with
cardiocirculatory
failure
and
multiple
system
organ
failure
within
12
-
24
hrs
from
start
of
treatment
.
This
model
of
lethal
systemic
capillary
leak
syndrome
with
multiple
system
organ
failure
differs
greatly
from
our
previous
sheep
model
of
acute
ventilator-induced
lung
injury
in
which
sheep
were
ventilated
with
a
peak
inspiratory
pressure
of
50
cm
H
2
O
,
a
respiratory
rate
of
4
breaths
x
min
(
-
1
)
,
and
an
inspiratory
time
of
1
.
35
secs
,
without
inducing
capillary
leak
syndrome
.
The
mere
change
of
respiratory
rate
from
4
to
8
breaths
x
min
(
-
1
)
,
with
a
near
doubling
of
the
inspiratory
time
to
2
.
5
secs
,
although
maintaining
eucapnia
,
resulted
in
lethal
systemic
capillary
leak
syndrome
and
multiple
system
organ
failure
with
both
gross
and
microscopic
pathology
of
lungs
greatly
different
from
our
previous
model
of
mechanical
ventilation-induced
acute
respiratory
distress
syndrome
.
Diseases
Validation
Diseases presenting
"cardiac dysfunction"
symptom
congenital diaphragmatic hernia
fabry disease
systemic capillary leak syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom