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Intraperitoneal photodynamic therapy causes a capillary-leak syndrome.
[systemic capillary leak syndrome]
In
patients
undergoing
intraperitoneal
(
IP
)
photodynamic
therapy
(
PDT
)
,
the
combination
of
aggressive
surgical
debulking
and
light
therapy
causes
an
apparent
systemic
capillary-leak
syndrome
that
necessitates
significant
intensive
care
unit
(
ICU
)
management
after
surgery
.
From
May
1997
to
May
2001
,
65
patients
underwent
surgical
debulking
and
PDT
as
part
of
an
ongoing
phase
II
trial
for
disseminated
IP
cancer
.
Perioperative
data
were
reviewed
retrospectively
,
and
statistical
analyses
were
performed
to
determine
whether
any
identifiable
factors
were
associated
with
the
need
for
mechanical
ventilation
for
longer
than
1
day
and
with
the
occurrence
of
postoperative
complications
.
Forty
-
three
women
and
22
men
(
mean
age
,
49
years
)
were
treated
.
Operative
time
averaged
9
.
8
hours
,
and
mean
estimated
blood
loss
was
1450
mL
.
The
mean
crystalloid
requirement
for
the
first
48
hours
after
surgery
was
29
.
3
L
,
and
49
patients
required
blood
products
.
Twenty
-
four
patients
were
intubated
for
longer
than
24
hours
,
with
a
mean
of
8
.
3
days
for
those
intubated
longer
than
1
day
.
The
median
ICU
stay
was
4
days
.
Overall
,
110
complications
developed
in
45
(
69
%
)
of
the
65
patients
.
Significant
complications
included
6
patients
with
acute
respiratory
distress
syndrome
,
28
patients
with
infectious
complications
,
and
4
patients
with
anastomotic
complications
.
Statistical
analyses
revealed
that
surgery-related
factors
were
significantly
associated
with
these
complication
outcomes
.
Patients
who
undergo
surgical
debulking
and
IP
PDT
develop
a
significant
capillary-leak
syndrome
after
surgery
that
necessitates
massive
volume
resuscitation
,
careful
ICU
monitoring
,
and
,
frequently
,
prolonged
ventilatory
support
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated