Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Intraperitoneal photodynamic therapy causes a capillary-leak syndrome.
[systemic capillary leak syndrome]
In
patients
undergoing
intraperitoneal
(
IP
)
photodynamic
therapy
(
PDT
)
,
the
combination
of
aggressive
surgical
debulking
and
light
therapy
causes
an
apparent
systemic
capillary-leak
syndrome
that
necessitates
significant
intensive
care
unit
(
ICU
)
management
after
surgery
.
From
May
1997
to
May
2001
,
65
patients
underwent
surgical
debulking
and
PDT
as
part
of
an
ongoing
phase
II
trial
for
disseminated
IP
cancer
.
Perioperative
data
were
reviewed
retrospectively
,
and
statistical
analyses
were
performed
to
determine
whether
any
identifiable
factors
were
associated
with
the
need
for
mechanical
ventilation
for
longer
than
1
day
and
with
the
occurrence
of
postoperative
complications
.
Forty
-
three
women
and
22
men
(
mean
age
,
49
years
)
were
treated
.
Operative
time
averaged
9
.
8
hours
,
and
mean
estimated
blood
loss
was
1450
mL
.
The
mean
crystalloid
requirement
for
the
first
48
hours
after
surgery
was
29
.
3
L
,
and
49
patients
required
blood
products
.
Twenty
-
four
patients
were
intubated
for
longer
than
24
hours
,
with
a
mean
of
8
.
3
days
for
those
intubated
longer
than
1
day
.
The
median
ICU
stay
was
4
days
.
Overall
,
110
complications
developed
in
45
(
69
%
)
of
the
65
patients
.
Significant
complications
included
6
patients
with
acute
respiratory
distress
syndrome
,
28
patients
with
infectious
complications
,
and
4
patients
with
anastomotic
complications
.
Statistical
analyses
revealed
that
surgery-related
factors
were
significantly
associated
with
these
complication
outcomes
.
Patients
who
undergo
surgical
debulking
and
IP
PDT
develop
a
significant
capillary-leak
syndrome
after
surgery
that
necessitates
massive
volume
resuscitation
,
careful
ICU
monitoring
,
and
,
frequently
,
prolonged
ventilatory
support
.
Diseases
Validation
Diseases presenting
"estimated blood loss was 1450 ml"
symptom
systemic capillary leak syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom