Rare Diseases Symptoms Automatic Extraction

[Monoclonal gammopathies].

[systemic capillary leak syndrome]

Monoclonal gammopathies can induce clinical or biological symptoms, independent of any associated hemopathy. Cryoglobulins types I and II are responsible for cutaneous lesions, peripheral neuropathy, and membranoproliferative glomerulopathy. Peripheral neuropathies associated with monoclonal gammopathy are chronic, distal, symmetrical and progressive, in two thirds of the cases the monoclonal component reacts with a neuronal antigen principally myelin associated glycoprotein. POEMS syndrome is characterized by: polyneuropathy, organomegaly, endocrine disorder, monoclonal component, and skin diseases. Deposits of light chains of immunoglobulins are responsible for a glomerulopathy, and sometimes affect other organs (skin, heart). Other manifestations are described: angioneurotic oedema, acquired Willebrand disease, systemic capillary leak syndrome, Fanconi syndrome. Treatment of the gammopathy can control associated affections.

Diseases presenting "skin diseases" symptom

  • cutaneous mastocytosis
  • dentinogenesis imperfecta
  • dracunculiasis
  • dystrophic epidermolysis bullosa
  • epidermolysis bullosa simplex
  • erythropoietic protoporphyria
  • fabry disease
  • harlequin ichthyosis
  • inclusion body myositis
  • junctional epidermolysis bullosa
  • kindler syndrome
  • lamellar ichthyosis
  • oculocutaneous albinism
  • papillon-lefèvre syndrome
  • sneddon syndrome
  • systemic capillary leak syndrome

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