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Two cases of systemic capillary leak syndrome that were treated with pentastarch.
[systemic capillary leak syndrome]
Systemic
capillary
leak
syndrome
(
SCLS
)
is
a
condition
that
's
caused
by
the
shift
of
fluid
and
protein
from
the
intravascular
space
to
the
interstitial
space
as
a
result
of
repetitive
episodes
of
capillary
hyperpermeability
.
The
pathogenesis
of
SCLS
is
still
unclear
,
but
there
's
recently
been
a
report
showing
this
syndrome
in
association
with
monoclonal
gammopathy
.
This
syndrome
can
be
a
fatal
disease
because
cardiovascular
collapse
can
occur
in
the
initial
capillary
leak
phase
.
Although
theophylline
,
diuretics
,
terbutaline
,
steroids
,
calcium
antagonist
,
Ginkgo
biloba
extracts
and
plasmapheresis
have
been
suggested
as
medication
,
none
of
them
have
been
proven
to
be
effective
.
Considering
that
this
disease
is
self-limiting
,
conservative
treatment
in
the
acute
phase
is
believed
to
be
very
important
.
Because
hypoalbuminemia
is
very
a
common
manifestation
of
SCLS
,
Pentastarch
,
which
has
a
higher
molecular
weight
than
albumin
,
could
be
efficient
to
prevent
cardiovascular
collapse
.
We
used
10
%
Pentastarch
during
the
acute
SCLS
attacks
of
2
patients
and
the
patients
both
showed
a
dramatic
response
.
Pentastarch
may
be
helpful
to
treat
SCLS
in
its
initial
capillary
leak
phase
by
the
elevating
blood
pressure
,
and
this
might
contribute
to
somewhat
decreasing
the
acute
mortality
of
SCLS
.
Diseases
Validation
Diseases presenting
"initial capillary leak phase"
symptom
systemic capillary leak syndrome
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