Synchronized changes in serum vascular endothelial growth factor during the clinical course of chronic systemic capillary leak syndrome.

[systemic capillary leak syndrome]

Systemic capillary leak syndrome (SCLS ) is a rare disease characterized by leakage of plasma from blood vessels into the interstitial space due to increased capillary permeability . We describe a 24 -year -old man who was hospitalized with systemic edema , hypoalbuminemia , and disseminated intravascular coagulation . After extensive investigative procedures , he was diagnosed with chronic SCLS and made a gradual recovery after starting on prednisolone , terbutaline , and theophylline . We measured the patient 's serum vascular endothelial growth factor (VEGF ) over time and found a relationship between serum VEGF and the clinical course .