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[Clinical manifestations associated with antiphospholipid antibodies].
[sneddon syndrome]
The
antiphospholipid
antibodies
are
immunoglobulins
able
to
join
negative
charge
phospholipids
.
The
have
been
related
to
a
great
variety
of
conditions
,
specially
among
connective
tissue
illness
although
the
idiopathic
form
seems
to
be
the
most
frequent
.
Their
presence
must
be
ruled
out
in
cases
of
young
patients
with
stroke
,
deep
veins
thrombosis
,
acute
heart
attack
and
woman
suffer
multiple
abortions
and
foetal
death
.
These
antibodies
appear
to
be
related
to
different
clinical
entities
like
Sneddon
syndrome
.
Evans
syndrome
,
"
chorea
gestationis
"
,
migraine
.
The
laboratory
determinations
are
based
in
direct
methods
(
ELISA
,
RIA
,
.
.
.
)
as
well
as
in
indirect
ones
(
activated
partial
thromboplastin
time
,
reptilase
time
,
.
.
.
)
.
The
appropriate
management
and
treatment
may
be
based
upon
clinical
expression
,
in
case
of
arterial
thrombosis
(
type
II
APS
)
,
or
deep
vein
thrombosis
(
Type
II
)
long
term
anticoagulation
is
indicated
;
Association
with
pentoxifylline
in
the
case
of
retinal
thrombosis
(
type
IIIa
)
,
Stroke
(
type
IIIb
)
cases
may
require
long
term
anticoagulation
as
well
as
aspirin
.
Type
IV
cases
are
better
managed
with
an
individualised
treatment
.
Diseases
Validation
Diseases presenting
"arterial thrombosis"
symptom
heparin-induced thrombocytopenia
sneddon syndrome
thoracic outlet syndrome
waldenström macroglobulinemia
This symptom has already been validated