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[Sneddon syndrome new clinical and immunological data].
[sneddon syndrome]
In
27
of
47
patients
with
Sneddon
's
syndrome
(
33
females
,
14
males
age
40
years
)
enzyme
immunoassay
has
detected
IgG-antibodies
to
prothrombin
(
aPT
)
-
-
one
of
cofactor
proteins
responsible
for
binding
of
antiphospholipid
antibodies
(
aPL
)
to
phospholipids
.
Other
aPL
were
also
found
:
antibodies
to
cardiolipin
(
aCL
)
,
lupus
anticoagulant
(
LA
)
in
14
and
27
patients
,
respectively
.
37
(
79
%
)
patients
had
at
least
one
of
the
studied
aPL
suggesting
that
such
patients
belong
to
patients
with
primary
antiphospholipid
syndrome
.
A
correlation
exists
between
aPT
and
LA
:
LA
is
detectable
in
67
%
of
aPT-
positive
patients
compared
to
45
%
of
aPT-negative
patients
(
p
<
0
.
05
)
.
This
is
in
agreement
with
the
fact
that
prothrombin
is
a
cofactor
for
most
aPL
registered
as
LA
.
Comparison
of
two
subgroups
of
aPL
patients
different
by
dominant
antigenic
specificity
(
18
patients
with
aPT
but
free
of
ACL
and
6
patients
with
aCP
but
free
of
aPT
)
demonstrated
that
the
latter
developed
disorders
of
cerebral
circulation
,
head
ache
,
dementia
and
renal
syndrome
less
frequently
.
aPT
in
Sneddon
's
syndrome
seems
to
be
a
marker
of
comparatively
low
risk
of
thrombosis
and
less
severe
course
of
the
disease
.