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[Antiphospholipid antibodies in a female patient with the Sneddon syndrome].
[sneddon syndrome]
Sneddon
was
the
first
one
to
describe
the
association
of
cerebrovascular
insult
(
CVI
)
and
skin
changes
by
livedo
reticularis
type
.
Angiography
of
this
patient
revealed
normal
brain
blood
vessels
,
occlusive
changes
or
the
changes
similar
to
those
in
moya-moya
disease
.
Computed
tomography
(
CT
)
of
the
brain
most
frequently
revealed
ischemic
lesions
and
/
or
diffuse
atrophy
of
the
brain
,
although
the
normal
finding
was
also
possible
.
Considering
the
frequent
finding
of
the
increased
titer
of
anticardiolipin
antibodies
(
ACA
)
in
those
patients
,
those
antibodies
could
be
the
most
important
in
the
pathogenesis
of
Sneddon
's
syndrome
.
A
case
of
female
patient
,
aged
66
years
,
with
livedo
reticularis
and
recurrent
CVI
was
presented
in
this
study
.
By
panangiography
were
revealed
normal
blood
vessels
of
the
brain
,
by
scintigraphy
two
ischemic
lesions
and
by
CT
ischemic
lesions
with
pronounced
cortical
and
subcortical
reductive
changes
.
In
laboratory
findings
were
observed
increased
immunocomplexes
and
the
presence
of
lupus-like
anticoagulants
,
increased
ACA
titer
,
the
increase
in
fibrinogen
value
associated
with
increased
ESR
.
The
result
of
bone
marrow
examination
was
normal
,
while
the
borreliosis
test
was
negative
.
Vasculitis
was
excluded
by
skin
biopsy
.
Solid
improvement
was
noticed
after
the
immunosuppresive
therapy
was
administered
,
but
in
the
last
disease
exacerbation
with
new
CVI
,
the
outcome
was
lethal
3
years
since
the
disease
onset
.
Diseases
Validation
Diseases presenting
"by scintigraphy two ischemic lesions and by ct ischemic lesions with pronounced cortical and subcortical reductive changes"
symptom
sneddon syndrome
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