Rare Diseases Symptoms Automatic Extraction
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Gradually progressive dementia without discrete cerebrovascular events in a patient with Sneddon's syndrome.
[sneddon syndrome]
A
37
-
year
-old
man
sought
medical
advice
because
of
an
8
-
year
history
of
a
slowly
progressive
dementing
illness
with
no
clinically
apparent
discrete
strokelike
episodes
.
Cognitive
functioning
was
markedly
,
globally
impaired
without
lateralizing
or
localizing
features
.
Widespread
livedo
reticularis
led
to
a
diagnosis
of
Sneddon
's
syndrome
.
Antiphospholipid
antibodies
and
lupus
anticoagulant
were
negative
.
Magnetic
resonance
imaging
showed
widespread
cerebral
atrophy
,
cortical
and
subcortical
cerebral
infarcts
,
and
extensive
periventricular
white
matter
abnormalities
.
Cerebral
angiography
revealed
diffuse
medium-
and
small
-vessel
occlusive
disease
,
with
numerous
collaterals
in
the
mid
and
distal
circulation
but
no
evidence
of
atherosclerosis
or
vasculitis
.
No
other
cause
of
a
dementing
illness
was
found
.
We
postulate
that
our
patient
's
dementia
was
due
to
the
cumulative
effects
of
multiple
cerebral
infarcts
.
Diseases
Validation
Diseases presenting
"periventricular white matter abnormalities"
symptom
sneddon syndrome
This symptom has already been validated
