Clinical and neuroradiological aspects of Sneddon's syndrome and primary antiphospholipid antibody syndrome. A follow-up study.

[sneddon syndrome]

We performed a study to investigate differences and similarities between patients with Sneddon 's syndrome and those with primary antiphospholipid syndrome (PAS ), by clinical follow-up , magnetic resonance imaging (MRI ) and angiography . Nine patients with Sneddon 's syndrome and 11 patients with PAS were assessed at diagnosis and followed for a mean of 6 years . The clinical and MRI findings indicated that Sneddon 's syndrome and PAS are distinct entities . Patients with Sneddon 's syndrome had a progressive clinical course with increasing disability and cognitive deterioration ; patients with PAS had a more benign course . Infarcts in territories of the main cerebral arteries were frequent in PAS , while leukoaraiosis and small lacunar infarcts were more common in Sneddon 's syndrome . In 3 of 7 women initially diagnosed with PAS , the diagnosis was changed to systemic lupus erythematosus during follow-up . Differential diagnosis of Sneddon 's syndrome and PAS is important , as early therapy is effective for the latter , more benign , condition .

Diseases
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Diseases presenting "progressive clinical course" symptom

homocystinuria without methylmalonic aciduria

sneddon syndrome

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