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Diagnostic impact and sensitivity of skin biopsies in Sneddon's syndrome. A report of 15 cases.
[sneddon syndrome]
Sneddon
's
syndrome
is
defined
as
a
combination
of
idiopathic
livedo
racemosa
generalisata
and
symptoms
of
cerebrovascular
defect
.
The
disease
usually
starts
with
vascular
symptoms
in
the
epidermis
,
with
neurological
deficits
becoming
evident
later
.
For
this
reason
,
histological
examination
of
skin
biopsies
and
determination
of
arteriolar
occlusion
is
of
particular
importance
for
reliable
categorization
and
early
diagnosis
.
To
date
,
these
methods
have
been
considered
to
be
too
insensitive
.
To
evaluate
the
sensitivity
of
skin
biopsies
in
Sneddon
's
syndrome
.
We
took
a
total
of
five
deep
punch
biopsies
(
4
mm
)
from
different
areas
of
the
livedo
(
three
from
white
and
two
from
red
areas
)
in
15
patients
.
Present
knowledge
of
the
pathogenic
relationships
and
the
particular
anatomical
features
of
the
skin
were
taken
into
account
.
The
method
had
a
sensitivity
of
27
%
with
one
biopsy
,
53
%
with
two
biopsies
and
80
%
with
three
biopsies
taken
from
white
areas
in
all
cases
.
Skin
biopsies
using
the
method
presented
achieved
a
high
sensitivity
,
suggesting
that
the
diagnosis
in
clinically
suspected
cases
could
be
confirmed
in
the
majority
of
cases
with
this
technique
.
Diseases
Validation
Diseases presenting
"suggesting that the diagnosis in clinically suspected cases could be confirmed in the majority of cases with this technique"
symptom
sneddon syndrome
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