Thrombophilia and stroke.

[sneddon syndrome]

Thrombophilia is defined as an enhanced tendency to form intravascular thrombi , which may be arterial or venous . Of the inherited thrombophilias , factor V Leiden and the prothrombin 2021 0 mutation have been associated with stroke , but this association is statistically significant only in children and adults under age 40 . The risk of stroke in persons with these mutations is substantially increased by concomitant exposure to oral contraceptives . Hyperhomocystinemia is a major risk factor for stroke as well as Alzheimer 's disease ; persons with deficiencies of vitamin B 12 or folic acid are especially vulnerable to these complications . Of the acquired thrombophilias , the antiphospholipid antibody syndrome is strongly associated with transient ischemic attacks , cerebral infarction , Sneddon syndrome , and dementia . The diagnosis of thrombophilia should be considered in stroke patients who are young , have a family history of thrombosis , suffer venous dural sinus thrombosis , or have recurrent strokes .

Diseases
Validation

Diseases presenting "but this association is statistically significant only in children and adults under age 40" symptom

sneddon syndrome

You can validate or delete this automatically detected symptom