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Sneddon's syndrome: clinical and laboratory analysis of 10 cases.
[sneddon syndrome]
Sneddon
's
syndrome
is
characterized
by
livedo
reticularis
and
cerebrovascular
lesions
.
We
report
the
cases
of
women
(
mean
age
,
36
.
2
+
/
-
8
.
1
years
)
diagnosed
with
Sneddon
's
syndrome
based
on
the
presence
of
livedo
reticularis
and
characteristic
cerebrovascular
findings
.
Seven
of
these
patients
had
cerebral
infarcts
on
cranial
computed
tomography
scan
.
Antiphospholipid
antibodies
were
positive
in
6
of
these
cases
.
Three
cases
had
abnormal
levels
of
antithrombin
III
.
Analyses
of
chromosome
6
revealed
no
abnormalities
.
In
3
of
the
cases
,
investigation
of
the
pedigrees
revealed
autosomal
dominant
traits
.
Two
cases
had
epilepsy
,
and
3
had
migraine
.
One
case
with
migraine
also
had
myasthenia
gravis
.
In
addition
,
we
detected
inferior
altudinal
hemianopia
in
2
cases
,
cognitive
functional
disorder
in
3
and
depression
in
2
.
Based
on
these
findings
,
the
entire
vascular
,
haematologic
,
neurologic
,
and
dermatologic
systems
should
be
evaluated
in
patients
diagnosed
with
Sneddon
's
syndrome
.
Diseases
Validation
Diseases presenting
"cerebral infarcts on cranial"
symptom
sneddon syndrome
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