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[Ischemic stroke at the young age: the role of antiphospholipid antibodies].
[sneddon syndrome]
Output
of
antiphospholipid
antibodies
(
aPL
)
coupled
with
arterial
and
/
or
venous
thromboses
,
miscarriage
and
some
other
clinical
manifestations
is
denoted
as
antiphospholipid
syndrome
(
APS
)
.
The
syndrome
is
primary
(
PAPS
)
in
the
absence
of
other
autoimmune
diseases
.
Arterial
thromboses
occur
most
frequently
in
the
cerebral
arteries
,
leading
to
ischemic
disorders
of
cerebral
circulation
(
DCC
)
.
The
present
work
summarises
the
results
of
our
own
studies
and
of
the
reported
data
on
DCC
in
PAPS
.
Their
characteristic
features
Include
the
relationship
with
occlusion
of
the
intracerebral
or
intracranial
rather
than
of
the
great
vessels
of
the
head
,
liability
for
recurrences
in
the
absence
of
secondary
prophylaxis
,
frequently
occurring
association
with
primary
disorder
of
cerebral
circulation
(
PDCC
)
,
good
restoration
of
the
focal
neurologic
deficit
after
the
first
stroke
,
more
frequent
development
in
women
.
The
clinical
recognition
of
DCC
which
stem
from
aPL
output
is
favoured
by
the
presence
in
the
patients
of
the
basic
non-
cerebral
signs
of
PAPS
(
miscarriage
peripheral
venous
thrombosis
,
myocardial
infarction
)
as
well
as
by
the
presence
of
the
additional
evidence
of
PAPS
(
livedo
,
induration
of
heart
valves
according
to
the
EchoCG
data
,
epileptic
syndrome
,
migraine
-like
headaches
,
chorea
in
the
anamnesis
,
and
so
forth
)
.
In
most
cases
,
they
precede
the
first
DCC
by
several
years
or
months
.
The
secondary
prophylaxis
of
DCC
in
PAPS
includes
the
intake
of
indirect
anticoagulants
and
.
small
doses
of
aspirin
.
Diseases
Validation
Diseases presenting
"absence of other autoimmune diseases"
symptom
sneddon syndrome
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