[Anti-phosphatidylethanolamine antibodies in patients with Sneddon's syndrome].

[sneddon syndrome]

Anti-phosphatidylethanolamine antibodies (aPE ) belong to the group of anti-phospholipid antibodies (aPL ) and are directed against neutral phospholipid , connected with co -factor protein , while cardiolipin antibodies (aKL ) are directed against negative phospholipid . The paper presents a study of prevalence and clinical significance of IgG aPE in 28 patients (22 women and 6 men , mean age 47 .6 +/- 11 .6 years ) with Sneddon 's syndrome (SS ), which consists in cerebrovascular disturbances and extensive livedo reticularis . IgG aPE were detected by immune-enzyme assay . The upper normal limit , calculated as mean + 3 SD after studying 19 healthy donors , was 0 .303 optic density units . aPE were found in 15 (54 %), aKL and /or lupus anticoagulant (LA )--in 6 (21 %) patients with SS . aPE were found in 10 (46 %) out of 22 aKL- and LA -negative patients . Among the aPE-positive patients there was a higher incidence of cortic dementia (53 % vs . 8 %, p = 0 .02 ), the widening of cortical sulci , detected by means of computed tomography and magnetic resonance imaging (73 % vs . 31 %, p = 0 .05 ), and mild renal syndrome (73 % vs . 16 %, p = 0 .03 ). Besides , they displayed a higher rate of headaches (87 % vs . 62 %), chorea (33 % vs . 8 %), epilepsy (27 % vs . 8 %), non-carrying of pregnancy (91 % vs . 50 %), peripheral venous thrombosis (27 % vs . 15 %), coronary heart disease (47 % vs . 31 %), cardiac valvular thickening , detected by means of EchoCG (93 % vs . 69 %), arterial hypertension (87 % vs . 54 %), thrombocytopenia (20 % vs . 0 ), anemia (40 % vs . 15 %); however , the difference was not significant . The results show that aPE detection , performed in addition to detection of classic immunological antiphospholipid syndrome markers (aKL and LA ), increases the portion of aPE-positive patients with SS by 33 %. aPE are often (in 46 % of cases ) found in aKL- and LA -negative patients with SS . aPE is likely to be the most significant factor of thrombosis in small arteries of the brain cortex and kidneys , which could explain their association with dementia and renal syndrome .

Diseases
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Diseases presenting "mild renal syndrome" symptom

sneddon syndrome

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