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Sneddon's syndrome: another migraine-stroke association?
[sneddon syndrome]
Sneddon
's
syndrome
refers
to
the
enigmatic
association
of
ischaemic
stroke
and
livedo
reticularis
.
We
review
the
Sneddon
's
syndrome
literature
examining
the
association
of
this
condition
with
headache
,
including
migraine
.
Case
reports
and
series
are
stratified
into
two
groups
based
on
headache
reference
.
In
the
group
without
a
reference
to
headache
,
there
are
208
persons
,
with
a
female
to
male
ratio
of
3
:
1
.
In
the
headache
reference
group
,
there
are
175
persons
,
with
a
female
to
male
ratio
of
3
.
5
:
1
.
The
proportion
with
headache
in
this
second
group
is
58
%
(
102
individuals
)
,
with
headache
described
as
migraine
in
28
(
27
.
5
%
)
of
the
headache
subjects
,
including
six
with
migraine
with
aura
.
The
frequency
of
headache
is
not
significantly
higher
in
persons
with
positive
anti-phospholipid
antibodies
compared
with
the
negative
cohort
(
43
%
vs
.
32
%
,
P
=
0
.
07
)
.
A
review
of
the
histopathological
,
radiological
and
serological
data
in
Sneddon
's
syndrome
and
migraine
underscores
the
plausibility
of
an
association
.
Considered
in
the
context
of
increased
risk
of
stroke
with
migraine
,
a
higher
frequency
of
livedo
in
migraineurs
with
stroke
,
and
the
association
of
migraine
and
livedo
reticularis
,
the
question
of
whether
livedo
reticularis
may
be
a
risk
marker
for
stroke
in
migraineurs
is
an
area
for
further
study
.
Diseases
Validation
Diseases presenting
"headache"
symptom
acute rheumatic fever
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
cadasil
cushing syndrome
cutaneous mastocytosis
erdheim-chester disease
esophageal squamous cell carcinoma
familial mediterranean fever
hereditary cerebral hemorrhage with amyloidosis
hydrocephalus with stenosis of the aqueduct of sylvius
legionellosis
locked-in syndrome
malignant atrophic papulosis
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
typhoid
von hippel-lindau disease
This symptom has already been validated
