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Histocompatibility class I and II antigens in extensive kindred with Sneddon's syndrome and related hypercoagulation disorders.
[sneddon syndrome]
We
have
studied
the
relationship
between
the
histocompatibility
class
I
and
II
antigens
and
Sneddon
's
syndrome
(
SS
)
in
a
Spanish
patient
with
SS
and
her
relatives
(
13
available
members
of
an
extensive
3
-
generation
pedigree
with
diverse
autoimmune
hypercoagulation
abnormalities
)
.
The
patient
and
her
father
were
diagnosed
with
a
primary
antiphospholipid
antibody
syndrome
and
were
HLA-A
30
-
B
13
-
Bw
6
.
In
addition
,
a
HLA-Bw
6
-
DQ
1
association
was
present
in
all
the
members
of
this
kindred
.
These
data
suggest
that
the
combination
of
the
histocompatibility
class
I
and
II
antigens
in
this
family
may
be
a
marker
for
predisposition
to
SS
.
Diseases
Validation
Diseases presenting
"a primary antiphospholipid antibody syndrome"
symptom
sneddon syndrome
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