Primary antiphospholipid syndrome with and without Sneddon's syndrome.

[sneddon syndrome]

The main objective of this study was to compare clinical and laboratory data obtained from patients with primary antiphospholipid syndrome (PAPS ) with and without Sneddon 's syndrome (SS ). A transverse study with 54 (85 .2 % female ) PAPS patients (Sapporo criteria ) was performed . Demographic , drug use , and antiphospholipid antibodies data were evaluated , as well as clinical and laboratory findings of SS . Patients were subdivided into one of two groups : PAPS with SS and PAPS without SS . Both groups were similar with respect to age (p Â =Â 0 .05 ), gender (p Â =Â 0 .34 ), race (p Â =Â 0 .31 ), weight (p Â =Â 0 .93 ), height (p Â =Â 0 .27 ), and body mass index (p Â =Â 0 .75 ); however , the SS group exhibited higher disease duration (96 .0 Â Â±Â 54 .9 vs . 55 .2 Â Â±Â 52 .0 Â months , p Â =Â 0 .01 ). By definition , all PAPS with SS patients suffer from stroke , an arterial event ; the frequency of stroke events (28 .5 vs . 7 .5 %, p Â =Â 0 .04 ), as well as of limb ischemia (100 vs . 30 .0 %, p Â <Â 0 .0001 ) was higher in this group than in the PAPS without SS group . On the other hand , patients in the PAPS without SS group had more venous events , such as deep venous thrombosis , than those in the PAPS with SS group (80 .0 vs . 50 .0 %, p Â =Â 0 .03 ). In conclusion , an understanding of the relationship between APS and SS is important in order to identify a subgroup for which more rigorous accompaniment and therapy may be necessary .

Diseases
Validation

Diseases presenting "venous events" symptom

sneddon syndrome

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