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Antiproliferative effects of TRPV1 ligands on nonspecific and enteroantigen-specific T cells from wild-type and Trpv1 KO mice.
[severe combined immunodeficiency]
Treatment
with
the
TRPV
1
agonist
,
capsaicin
,
was
previously
shown
to
protect
against
experimental
colitis
in
the
severe
combined
immunodeficiency
(
SCID
)
T
-
cell
transfer
model
.
Here
,
we
investigate
trpv
1
gene
expression
in
lymphoid
organs
and
cells
from
SCID
and
BALB
/
c
mice
to
identify
a
potential
target
for
the
anti-
inflammatory
effect
of
capsaicin
.
The
trpv
1
expression
was
studied
by
real-time
PCR
in
lymphoid
tissues
and
gut
of
untreated
and
capsaicin-treated
colitic
SCID
mice
.
Effects
of
capsaicin
and
a
TRPV
1
antagonist
on
T
cells
were
studied
in
vitro
.
In
contrast
to
BALB
/
c
mice
,
spleen
,
lymph
nodes
,
and
rectum
of
colitic
and
noncolitic
SCID
mice
express
trpv
1
mRNA
.
Capsaicin
treatment
in
vivo
attenuated
T
-
cell
transfer
colitis
and
capsaicin
in
vitro
also
attenuated
T
-
cell
proliferation
induced
by
enteroantigen
,
mitogen
,
and
anti-
CD
3
/
CD
28
beads
in
BALB
/
c
,
C
5
7
BL
/
6
mice
,
and
B
6
.
129
X
1
-
trpv
1
tm
1
J
ul
/
J
trpv
1
knockout
mice
.
Proliferation
and
cytokine
secretion
were
fully
comparable
in
mice
with
and
without
trpv
1
expression
.
Likewise
,
enteroantigen-
and
mitogen-stimulated
T
cells
from
wild-
type
and
trpv
1
knockout
mice
were
equally
inhibited
by
capsaicin
.
Surprisingly
,
the
TRPV
1
antagonist
BCTC
also
inhibited
enteroantigen-
and
mitogen-induced
T
-
cell
proliferation
.
T
he
trpv
1
mRNA
expression
in
lymphoid
organs
and
the
rectum
of
SCID
mice
suggests
that
the
TRPV
1
signaling
in
these
organs
could
play
a
role
in
capsaicin-mediated
attenuation
of
colitis
.
In
addition
,
capsaicin-induced
inhibition
of
T
-
cell
proliferation
of
wild-
type
T
cells
lacking
trpv
1
expression
suggests
that
capsaicin
inhibits
colitogenic
T
cells
in
a
TRPV
1
receptor-independent
way
,
which
might
be
linked
to
its
anti-
inflammatory
effect
.
Diseases
Validation
Diseases presenting
"capsaicin in vitro also attenuated t-cell proliferation induced by enteroantigen"
symptom
severe combined immunodeficiency
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