Rare Diseases Symptoms Automatic Extraction
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Severe combined immunodeficiency mouse-psoriatic human skin xenograft model: a modern tool connecting bench to bedside.
[severe combined immunodeficiency]
Psoriasis
is
a
multifactorial
chronic
inflammatory
disease
.
Research
into
the
pathogenesis
of
this
disease
is
hindered
by
the
lack
of
a
proper
animal
model
.
Over
the
past
two
decades
,
many
scientists
were
involved
in
the
development
of
animal
models
that
nearly
mirror
the
immunopathogenesis
of
psoriasis
.
One
such
model
,
which
has
opened
doors
to
the
study
of
molecular
complexities
of
psoriasis
as
well
as
its
treatment
,
is
the
severe
combined
immunodeficiency
(
SCID
)
mouse-human
skin
chimera
model
.
This
model
not
only
mirrors
the
clinical
and
histopathological
features
of
psoriasis
but
also
help
in
the
study
of
cell
proliferation
,
angiogenesis
,
function
of
T
cells
,
neurogenic
inflammation
and
cytokines
involved
in
inflammatory
reactions
.
In
this
article
,
we
have
reviewed
the
prospects
and
the
limitations
of
the
SCID
mouse
model
of
psoriasis
.
Diseases
Validation
Diseases presenting
"psoriasis"
symptom
cushing syndrome
epidermolysis bullosa simplex
harlequin ichthyosis
hodgkin lymphoma, classical
lamellar ichthyosis
omenn syndrome
severe combined immunodeficiency
systemic capillary leak syndrome
werner syndrome
This symptom has already been validated