Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Virgin olive oil phenolics extract inhibit invasion of HT115 human colon cancer cells in vitro and in vivo.
[severe combined immunodeficiency]
The
decreased
cancer
risk
associated
with
consumption
of
olive
oil
may
be
due
to
the
presence
of
phenolics
which
can
modulate
pathways
including
apoptosis
and
invasion
that
are
relevant
to
carcinogenesis
.
We
have
previously
shown
that
a
virgin
olive
oil
phenolics
extract
(
OVP
)
inhibited
invasion
of
HT
115
colon
cancer
cells
in
vitro
.
In
the
current
study
we
assessed
the
in
vitro
effects
of
OVP
(
25
μg
mL
(
-
1
)
)
on
HT
115
cell
migration
,
spreading
and
integrin
expression
.
Furthermore
,
the
anti-metastatic
activity
of
OVP
-
at
a
dose
equivalent
to
25
mg
per
kg
per
day
for
2
,
8
or
10
weeks
-
was
assessed
in
a
Severe
Combined
ImmunoDeficiency
(
SCID
)
Balb-c
mouse
model
.
After
24
h
OVP
did
not
inhibit
cell
migration
but
significantly
reduced
cell
spreading
on
fibronectin
(
65
%
of
control
;
p
<
0
.
05
)
and
expression
of
a
range
of
α
and
β
integrins
was
modulated
.
In
vivo
,
OVP
by
gavage
significantly
(
p
<
0
.
05
)
decreased
not
only
tumour
volume
but
also
the
number
of
metastases
in
SCID
Balb-c
mice
.
Collectively
,
the
data
suggest
that
-
possibly
through
modulation
of
integrin
expression
-
OVP
decreases
invasion
in
vitro
and
also
inhibits
metastasis
in
vivo
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
