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Virgin olive oil phenolics extract inhibit invasion of HT115 human colon cancer cells in vitro and in vivo.
[severe combined immunodeficiency]
The
decreased
cancer
risk
associated
with
consumption
of
olive
oil
may
be
due
to
the
presence
of
phenolics
which
can
modulate
pathways
including
apoptosis
and
invasion
that
are
relevant
to
carcinogenesis
.
We
have
previously
shown
that
a
virgin
olive
oil
phenolics
extract
(
OVP
)
inhibited
invasion
of
HT
115
colon
cancer
cells
in
vitro
.
In
the
current
study
we
assessed
the
in
vitro
effects
of
OVP
(
25
μg
mL
(
-
1
)
)
on
HT
115
cell
migration
,
spreading
and
integrin
expression
.
Furthermore
,
the
anti-metastatic
activity
of
OVP
-
at
a
dose
equivalent
to
25
mg
per
kg
per
day
for
2
,
8
or
10
weeks
-
was
assessed
in
a
Severe
Combined
ImmunoDeficiency
(
SCID
)
Balb-c
mouse
model
.
After
24
h
OVP
did
not
inhibit
cell
migration
but
significantly
reduced
cell
spreading
on
fibronectin
(
65
%
of
control
;
p
<
0
.
05
)
and
expression
of
a
range
of
α
and
β
integrins
was
modulated
.
In
vivo
,
OVP
by
gavage
significantly
(
p
<
0
.
05
)
decreased
not
only
tumour
volume
but
also
the
number
of
metastases
in
SCID
Balb-c
mice
.
Collectively
,
the
data
suggest
that
-
possibly
through
modulation
of
integrin
expression
-
OVP
decreases
invasion
in
vitro
and
also
inhibits
metastasis
in
vivo
.