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Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer.
[severe combined immunodeficiency]
We
investigated
the
expression
status
of
AGBL
2
and
its
inhibitor
latexin
in
breast
cancer
stem
cells
and
its
clinical
implications
in
order
to
lay
a
foundation
for
managing
breast
cancer
.
C
D
44
+
/
CD
24
-
tumor
cells
(
CSC
)
from
clinical
specimens
were
sorted
using
flow
cytometry
.
AGBL
2
expression
status
was
detected
in
CSC
and
126
breast
cancer
specimens
by
western
blot
and
immunohistochemistry
staining
.
The
relationship
between
the
AGBL
2
protein
and
clinicopathological
parameters
and
prognosis
was
subsequently
determined
.
As
a
result
,
CSC
are
more
likely
to
generate
new
tumors
in
mice
and
cell
microspheres
that
are
deficient
in
non-obese
diabetic
/
severe
combined
immunodeficiency
mice
(
NOD
/
SCID
)
compared
to
the
control
group
.
The
AGBL
2
protein
was
expressed
higher
in
CSC
induced
to
epithelial
to
mesenchymal
transition
(
EMT
)
when
compared
to
the
control
cells
,
and
was
found
to
be
related
to
CSC
chemotherapy
resistance
.
After
Spearman
regression
correlation
analysis
,
AGBL
2
was
observed
to
be
related
to
clinical
stage
,
histological
stage
,
and
lymph
node
metastasis
.
In
the
Cox
regression
test
,
the
AGBL
2
protein
was
detected
as
an
independent
prognostic
factor
.
Through
immunoprecipitation
,
AGBL
2
and
latexin
could
form
immune
complexes
.
These
results
demonstrate
that
AGBL
2
is
a
latexin
-interacting
protein
that
regulates
the
tubulin
tyrosination
cycle
and
is
a
potential
target
for
intervention
.
Diseases
Validation
Diseases presenting
"breast cancer"
symptom
acute rheumatic fever
aromatase deficiency
carcinoma of the gallbladder
child syndrome
cowden syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
oral submucous fibrosis
proteus syndrome
severe combined immunodeficiency
systemic capillary leak syndrome
von hippel-lindau disease
waldenström macroglobulinemia
werner syndrome
wiskott-aldrich syndrome
This symptom has already been validated