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Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T Cells.
[severe combined immunodeficiency]
Adoptive
immunotherapy
with
antigen-
specific
T
cells
has
shown
promise
for
the
treatment
of
malignancies
.
However
,
infused
T
cells
are
unable
to
redirect
resident
T
cells
,
limiting
potential
benefit
.
While
the
infusion
of
bispecific
T
-
cell
engagers
can
redirect
resident
T
cells
to
tumors
,
these
molecules
have
a
short
half
-life
,
and
do
not
self
amplify
.
To
overcome
these
limitations
,
we
generated
T
cells
expressing
a
secretable
T
-
cell
engager
specific
for
CD
3
and
EphA
2
,
an
antigen
expressed
on
a
broad
range
of
human
tumors
(
EphA
2
-
ENG
T
cells
)
.
EphA
2
-
ENG
T
cells
were
activated
and
recognized
tumor
cells
in
an
antigen-dependent
manner
,
redirected
bystander
T
cells
to
tumor
cells
,
and
had
potent
antitumor
activity
in
glioma
and
lung
cancer
severe
combined
immunodeficiency
(
SCID
)
xenograft
models
associated
with
a
significant
survival
benefit
.
This
new
class
of
tumor
-
specific
T
cells
,
with
the
unique
ability
to
redirect
bystander
T
cells
,
may
be
a
promising
alternative
to
current
immunotherapies
for
cancer
.
Molecular
Therapy
(
2014
)
;
doi
:
10
.
1038
/
mt
.
2014
.
156
.
Diseases
Validation
Diseases presenting
"redirected bystander t cells to tumor cells"
symptom
severe combined immunodeficiency
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