Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Activation of antitumor immune responses by Ganoderma formosanum polysaccharides in tumor-bearing mice.
[severe combined immunodeficiency]
Fungi
of
the
genus
Ganoderma
are
basidiomycetes
that
have
been
used
as
traditional
medicine
in
Asia
and
have
been
shown
to
exhibit
various
pharmacological
activities
.
We
recently
found
that
PS-
F
2
,
a
polysaccharide
fraction
purified
from
the
submerged
culture
broth
of
Ganoderma
formosanum
,
stimulates
the
maturation
of
dendritic
cells
and
primes
a
T
helper
1
(
Th
1
)
-
polarized
adaptive
immune
response
in
vivo
.
In
this
study
,
we
investigated
whether
the
immune
adjuvant
function
of
PS-
F
2
can
stimulate
antitumor
immune
responses
in
tumor
-bearing
mice
.
Continuous
intraperitoneal
or
oral
administration
of
PS-
F
2
effectively
suppressed
the
growth
of
colon
26
(
C
2
6
)
adenocarcinoma
,
B
16
melanoma
,
and
sarcoma
180
(
S
180
)
tumor
cells
in
mice
without
adverse
effects
on
the
animals
'
health
.
PS-
F
2
did
not
cause
direct
cytotoxicity
on
tumor
cells
,
and
it
lost
the
antitumor
effect
in
mice
with
severe
combined
immunodeficiency
(
SCID
)
.
CD
4
(
+
)
T
cells
,
CD
8
(
+
)
T
cells
,
and
serum
from
PS-
F
2
-
treated
tumor
-bearing
mice
all
exhibited
antitumor
activities
when
adoptively
transferred
to
naïve
animals
,
indicating
that
PS-
F
2
treatment
stimulates
tumor
-
specific
cellular
and
humoral
immune
responses
.
These
data
demonstrate
that
continuous
administration
of
G
.
formosanum
polysaccharide
PS-
F
2
can
activate
host
immune
responses
against
ongoing
tumor
growth
,
suggesting
that
PS-
F
2
can
potentially
be
developed
into
a
preventive
/
therapeutic
agent
for
cancer
immunotherapy
.
Diseases
Validation
Diseases presenting
"and it lost the antitumor effect in mice with severe combined immunodeficiency"
symptom
severe combined immunodeficiency
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom