Cover picture: eur. J. Immunol. 10'14.

[severe combined immunodeficiency]

This month 's cover features an in silico modeling of the Î³c R 222 C protein . The distribution of the electrostatic potential is shown in red for the negative charges , and in blue for the positive charges . The image is taken from the article by Fuchs et al . (pp . 3129 -3140 ), where the authors analyzed the T -, B-, and NK-cell functional responses to Î³c-dependent cytokines in patients with the IL 2 RGR 222 C mutation , which is relatively frequent in the most common form of severe combined immunodeficiency (X-SCID ). In IL 2 (RGR 222 C ) patients , the signaling of Î³c cytokines for developmental processes was sufficient , whereas peripheral differentiation and function of lymphocytes was significantly impaired . The authors suggest that impaired T -cell immunity may not fully explain the phenotype , but the defects in several cytokine pathways leading to impaired NK-cell and B-cell immunity may contribute to the severe infection susceptibility .

Diseases
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Diseases presenting "il2rgr222c mutation" symptom

severe combined immunodeficiency

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